Whole genome sequencing reveals host factors underlying critical Covid-19.
(Genes & Health contributed as one of many international cohorts to the multiple phenotype analyses of the COVID-19 Host Genetics Initiative release 6)
Nature 2022. DOI https://doi.org/10.1038/s41586-022-04576-6
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistanis and Bangladeshis
medRxiv 2021 https://www.medrxiv.org/content/10.1101/2021.06.22.21259323v1
Harnessing the power of polygenic risk scores to predict type 2 diabetes and its subtypes in a high-risk population of British Pakistanis and Bangladeshis in a routine healthcare setting
medRxiv 2021 https://www.medrxiv.org/content/10.1101/2021.07.12.21259837v1
Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases
medRxiv 2021 https://doi.org/10.1101/2021.11.19.21266436
The power of genetic diversity in genome-wide association studies of lipids.
Nature 2021. DOI https://doi.org/10.1038/s41586-021-04064-3
MC3R links nutritional state to childhood growth and the timing of puberty.
Nature 2021. DOI https://doi.org/10.1038/s41586-021-04088-9
Mapping the human genetic architecture of COVID-19.
Nature 2021 https://doi.org/10.1038/s41586-021-03767-x
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
Nature 2020. DOI https://doi.org/10.1038/s41586-020-2818-3
Genetic mechanisms of critical illness in Covid-19.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
Nature 2020. DOI https://doi.org/10.1038/s41586-020-03065-y
Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations.
Cell 2020 Sept 3. DOI https://doi.org/10.1016/j.cell.2020.06.045
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
New England Journal of Medicine 2020 Jun 17. DOI https://doi.org/10.1056/NEJMoa2020283
Evaluating potential drug targets through human loss-of-function genetic variation.
Nature 2020 May;581(7809):459-464. DOI https://doi.org/10.1101/530881
Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.
eLife 2020;9:e54363. DOI https://doi.org/10.7554/eLife.54363
Cohort Profile: East London Genes & Health (ELGH), a community based population genomics and health study in people of British-Bangladeshi and -Pakistani heritage.
International Journal of Epidemiology 2019 Feb, 49(1), 20–21i. DOI https://doi.org/10.1093/ije/dyz174
Effects of autozygosity on a broad range of human phenotypes.
Nature Communications 2019 Oct 31;10(1):4957. DOI https://doi.org/10.1038/s41467-019-12283-6
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Nature Communications 2018 Feb 19;9(1):711. DOI https://doi.org/10.1038/s41467-018-03109-y
Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.
Nature Communications 2017 Aug 21;8(1):303. DOI https://doi.org/10.1038/s41467-017-00323-y
Health and population effects of rare gene knockouts in adult humans with related parents.
Science 2016 Apr 22;352(6284):474-7. DOI https://doi.org/10.1126/science.aac8624
