(last updated 19 May 2023)
Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease
manuscript accepted (Nature Medicine) 2023 & https://www.medrxiv.org/content/10.1101/2023.03.03.23286649v1
Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom
Scientific Reports 2023, https://doi.org/10.1038/s41598-023-33391-w
A second update on mapping the human genetic architecture of COVID-19
(Genes & Health contributed as one of many international cohorts to the multiple phenotype analyses of the COVID-19 Host Genetics Initiative)
manuscript accepted (Nature), 2023 & https://www.medrxiv.org/content/10.1101/2022.12.24.22283874v2
Influence of autozygosity on common disease risk across the phenotypic spectrum
manuscript submitted, 2023 & https://www.medrxiv.org/content/10.1101/2023.02.01.23285346v1
Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension
manuscript accepted (Nature Medicine), 2023 & https://www.medrxiv.org/content/10.1101/2022.11.30.22282929v1
Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
manuscript submitted, 2023 & https://www.biorxiv.org/content/10.1101/2022.07.20.500802v1
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genome Biology 2022. https://doi.org/10.1186/s13059-022-02837-1
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
(Genes & Health contributed as one of 24 international biobanks)
Cell Genomics 2022. DOI https://doi.org/10.1016/j.xgen.2022.100192
A first update on mapping the human genetic architecture of COVID-19
(Genes & Health contributed as one of many international cohorts to the multiple phenotype analyses of the COVID-19 Host Genetics Initiative)
Nature 2022. DOI: https://doi.org/10.1038/s41586-022-04826-7
Whole genome sequencing reveals host factors underlying critical Covid-19.
(Genes & Health contributed as one of many international cohorts to the multiple phenotype analyses of the COVID-19 Host Genetics Initiative release 6)
Nature 2022. DOI https://doi.org/10.1038/s41586-022-04576-6
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistanis and Bangladeshis
Nature Communications 2022. DOI https://doi.org/10.1038/s41467-022-32095-5
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
American Journal of Human Genetics 2022. DOI https://doi.org/10.1016/j.ajhg.2022.06.012
Harnessing the power of polygenic risk scores to predict type 2 diabetes and its subtypes in a high-risk population of British Pakistanis and Bangladeshis in a routine healthcare setting
PLOS Medicine 2022. DOI https://doi.org/10.1371/journal.pmed.1003981
The power of genetic diversity in genome-wide association studies of lipids.
Nature 2021. DOI https://doi.org/10.1038/s41586-021-04064-3
MC3R links nutritional state to childhood growth and the timing of puberty.
Nature 2021. DOI https://doi.org/10.1038/s41586-021-04088-9
Mapping the human genetic architecture of COVID-19.
(Genes & Health contributed as one of many international cohorts to the multiple phenotype analyses of the COVID-19 Host Genetics Initiative)
Nature 2021 https://doi.org/10.1038/s41586-021-03767-x
Fine-scale population structure and demographic history of British Pakistanis
Nature Communications 2021 https://doi.org/10.1038/s41467-021-27394-2
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
Nature 2020. DOI https://doi.org/10.1038/s41586-020-2818-3
Genetic mechanisms of critical illness in Covid-19.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
Nature 2020. DOI https://doi.org/10.1038/s41586-020-03065-y
Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations.
Cell 2020 Sept 3. DOI https://doi.org/10.1016/j.cell.2020.06.045
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
(Genes & Health contributed as one of 8 international cohorts to the hospitalised inpatient phenotype analysis of the COVID-19 Host Genetics Initiative)
New England Journal of Medicine 2020 Jun 17. DOI https://doi.org/10.1056/NEJMoa2020283
Evaluating potential drug targets through human loss-of-function genetic variation.
Nature 2020 May;581(7809):459-464. DOI https://doi.org/10.1101/530881
Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.
eLife 2020;9:e54363. DOI https://doi.org/10.7554/eLife.54363
Cohort Profile: East London Genes & Health (ELGH), a community based population genomics and health study in people of British-Bangladeshi and -Pakistani heritage.
International Journal of Epidemiology 2019 Feb, 49(1), 20–21i. DOI https://doi.org/10.1093/ije/dyz174
Effects of autozygosity on a broad range of human phenotypes.
Nature Communications 2019 Oct 31;10(1):4957. DOI https://doi.org/10.1038/s41467-019-12283-6
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Nature Communications 2018 Feb 19;9(1):711. DOI https://doi.org/10.1038/s41467-018-03109-y
Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.
Nature Communications 2017 Aug 21;8(1):303. DOI https://doi.org/10.1038/s41467-017-00323-y
Health and population effects of rare gene knockouts in adult humans with related parents.
Science 2016 Apr 22;352(6284):474-7. DOI https://doi.org/10.1126/science.aac8624
