• Queen Mary University of London
  • Barts Health NHS
  • Bradford NHS

Scientific data downloads

Scientific data downloads

Downloads

This includes variant calls (single nucleotide variants and small insertions/deletions) from 8086 (mostly British Pakistani/British Bangladeshi) individuals from the following studies: 1. 3781 British Pakistani/British Bangladeshi adults from East London Genes and Health 2. 2791 British South Asian mothers from Born in Bradford 3. 1428 British South Asian adults from Birmingham 4.

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The updated files below contain lists of predicted loss of function (LoF) and functional (missense or inframe indels) variants in the current Genes & Health callset, released in November 2017.

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PRELIMINARY DATA - USE WITH CAUTION

These files contain exome sequencing data on loss of function variants from 3782 East London Genes & Health volunteers (Bangladeshi and Pakistani, with self-stated related parents), 2624 Bradford volunteers (Pakistani, mostly self-stated or DNA autozygous individuals), 1060 Birmingham volunteers (Pakistani, unselected). Bradford and Birmingham samples are as described in Narasimhan et al Science 2016, with additional Bradford samples.

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** UPDATED 11 Apr 2017 - previous file was missing some chr1 variants **

 

This compressed file is from sequencing of 1687 self-stated parentally-related individuals living in East London.

All volunteers are of (British-) Bangladeshi and (British-) Pakistani ethnic origin.

Loss of function variant sites (exome capture, Agilent reagent) as called by the consensus of samtools and GATK, and genome annotation by LOFTEE.

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We will also make full processed data available via the European Genome-phenome Archive, subject to Data Access Agreement, within 6 months of data generation.

This is a condition of Wellcome Trust funding.

Website: https://www.ebi.ac.uk/ega/

 

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